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[4] [37] Substrate + NADPH + H + → 5α-substrate + NADP + Beyond being a catalyst in the rate-limiting step in testosterone reduction, 5α-reductase isoforms I and II reduce progesterone to 5α-dihydroprogesterone (5α-DHP) and deoxycorticosterone to dihydrodeoxycorticosterone (DHDOC)

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[DOI] [PubMed] [PMC] Goffredo M, Santoro N, Tricò D, Giannini C, D’Adamo E, Zhao H, et al